Retinoschisis is best described as splitting of the retina between which layers?

Retinoschisis is best described as splitting of the retina between which layers?

• A. INL and OPL
• B. NFL and GCL
• C. RPE and photoreceptor
• D. ONL and ISL

Answer: (A)

Retinoschisis is a splitting of retinal tissue that creates cavities within the inner retina, not a detachment from the retinal pigment epithelium. The classic plane of separation is at the boundary between the inner nuclear layer and the outer plexiform layer, so the schisis cavity forms between the INL and OPL. On imaging, you’d see a cystic space within the INL adjacent to the INL-OPL junction. The other options describe splits in different locations (toward the ganglion cell layer border or in the outer retina/subretinal space) that do not match where retinoschisis typically occurs.

Retinoschisis is a splitting of retinal tissue that creates cavities within the inner retina, not a detachment from the retinal pigment epithelium. The classic plane of separation is at the boundary between the inner nuclear layer and the outer plexiform layer, so the schisis cavity forms between the INL and OPL. On imaging, you’d see a cystic space within the INL adjacent to the INL-OPL junction. The other options describe splits in different locations (toward the ganglion cell layer border or in the outer retina/subretinal space) that do not match where retinoschisis typically occurs.