Retinoschisis occurs specifically between which two retinal layers?

Retinoschisis occurs specifically between which two retinal layers?

• A. INL and OPL
• B. NFL and GCL
• C. RPE and photoreceptor
• D. ONL and ISL

Answer: (A)

Retinoschisis is a splitting of retinal tissue, and in most cases it occurs at the junction between the inner nuclear layer and the outer plexiform layer. This INL-OPL interface is where the connections between certain retinal neurons (like bipolar and horizontal cells) are maintained by adhesion proteins such as retinoschisin. When these adhesions weaken, fluid accumulates and a schisis cavity forms here, often predominantly in the inner nuclear layer. The other interfaces listed — such as the nerve fiber layer with the ganglion cell layer, or the boundary between the RPE and photoreceptors, or the outer nuclear layer with the inner segments — are not the typical sites for retinoschisis, which is why the INL-OPL boundary is the best answer.

Retinoschisis is a splitting of retinal tissue, and in most cases it occurs at the junction between the inner nuclear layer and the outer plexiform layer. This INL-OPL interface is where the connections between certain retinal neurons (like bipolar and horizontal cells) are maintained by adhesion proteins such as retinoschisin. When these adhesions weaken, fluid accumulates and a schisis cavity forms here, often predominantly in the inner nuclear layer. The other interfaces listed — such as the nerve fiber layer with the ganglion cell layer, or the boundary between the RPE and photoreceptors, or the outer nuclear layer with the inner segments — are not the typical sites for retinoschisis, which is why the INL-OPL boundary is the best answer.