What is Bruch's membrane?

What is Bruch's membrane?

• A. Bruch's membrane is located between the retinal pigment epithelium (RPE) and the choriocapillaris in the eye.
• B. Bruch's membrane is the outermost layer of the sclera.
• C. Bruch's membrane lines the inner surface of the cornea.
• D. Bruch's membrane is a component of the iris stroma.

Answer: (A)

Bruch's membrane is the thin, multi-layer interface between the retinal pigment epithelium (RPE) and the choroid, specifically sitting between the RPE and the choriocapillaris. It acts as a diffusion barrier and support for metabolite exchange, helping nutrients reach photoreceptors from the blood and guiding waste products away. Its location here means that age-related changes or lipid deposits in Bruch's membrane can disrupt this exchange, contributing to retinal diseases like age-related macular degeneration. It is not part of the sclera, the inner surface of the cornea, or the iris stroma, which are structures outside the retina–choroid interface.

Bruch's membrane is the thin, multi-layer interface between the retinal pigment epithelium (RPE) and the choroid, specifically sitting between the RPE and the choriocapillaris. It acts as a diffusion barrier and support for metabolite exchange, helping nutrients reach photoreceptors from the blood and guiding waste products away. Its location here means that age-related changes or lipid deposits in Bruch's membrane can disrupt this exchange, contributing to retinal diseases like age-related macular degeneration. It is not part of the sclera, the inner surface of the cornea, or the iris stroma, which are structures outside the retina–choroid interface.